Compression of LC/MS Proteomic Data

Author

Miguel, Agnieszka C. ; Keane, John F. ; Whiteaker, J. ; Zhang, Jeffrey WhiteakerHeidi ; Paulovich, Amanda

Author_Institution

Dept. of Electr. & Comput. Eng., Seattle Univ., WA

fYear

2006

fDate

22-23 June 2006

Firstpage

925

Lastpage

930

Abstract

The unrelenting growth of mass spectrometry (MS) based proteomic data to gigabytes per sample and terabytes per experiment motivates this investigation into compression methods suited to MS signal sources. The data for this study was derived from peptides of hand-mixed protein samples passed through a high performance liquid chromatography system (HPLC) and an electrospray ionization time-of-flight (ESI-TOF) mass spectrometer. Several lossless data compression methods were applied and yielded up to a 25:1 compression ratio relative to the original files containing base64 encoding of the data

Keywords

biology computing; chromatography; data compression; ionisation; mass spectroscopic chemical analysis; molecular biophysics; proteins; time of flight mass spectra; HPLC; LC/MS proteomic data; base64 encoding; compression methods; electrospray ionization time-of-flight mass spectrometer; hand-mixed protein samples; high performance liquid chromatography; lossless data compression methods; mass spectrometry; peptides; Cancer; Data analysis; Data compression; Instruments; Ionization; Mass spectroscopy; Peptides; Performance analysis; Proteins; Proteomics;

fLanguage

English

Publisher

ieee

Conference_Titel

Computer-Based Medical Systems, 2006. CBMS 2006. 19th IEEE International Symposium on

Conference_Location

Salt Lake City, UT

ISSN

1063-7125

Print_ISBN

0-7695-2517-1

Type

conf

DOI

10.1109/CBMS.2006.2

Filename

1647688