Enhancement of the DNA microarray chip images

In this paper a novel method of noise reduction in color images is presented. The new technique is capable of attenuating both impulsive and Gaussian noise, while preserving and even enhancing the sharpness of the image edges. Extensive simulations reveal that the new method outperforms significantly the standard techniques widely used in multivariate signal processing. In this work we apply the new noise reduction method for the enhancement of the images of gene chips. We demonstrate that the new technique is capable of reducing various kinds of noise present in microarray images and that it enables efficient spot location and estimation of the gene expression level, due to the smoothing effect and preservation of the spot edges. This paper contains the comparison of the new technique of noise reduction with the standard procedures used for the processing of vector valued images, as well as examples of the efficiency of the new algorithm when applied to typical microarray images.