Altered GABAA receptor expression as biomarker of mercury toxicity in embryonic neurogenesis

Author

Ayensu, Wellington K. ; Isokpehi, Raphael D. ; Cohly, Hari H. ; Murray, Jessica M. ; Webb, Demareo J. ; Tchounwou, Paul B.

Author_Institution

Dept. of Biol., Jackson State Univ., Jackson, MS

fYear

2009

fDate

18-19 March 2009

Firstpage

1

Lastpage

3

Abstract

Mouse brain microarray dataset (GDS2702) on embryonic days 14.5 (E14.5), 16.5 (E16.5) and 18.5 (E18.5) was investigated for gene expression patterns of GABA receptors. Gabbr1, Gabra2, Gabrb3 and Gabrg2 were the only four GABA receptor genes expressed at stage E14.5 and E16.5. However, at stage E18.5, four additional genes (Gabra1, Gabra3, Gabrg1 and Gabrg3) were expressed. Gabbr1 had the highest intensity in all the three embryonic days. Gabra6, Gabrb2, Gabrd, Gabrr1 and Gabrr2 were not expressed in all the 3 samples analyzed. It is proposed that Gabra6 receptor is a potential biomarker for neuronal toxicity that can arise from maternal exposures to low doses of mercury through diet, water and air pollutions.

Keywords

biochemistry; genetics; neurophysiology; obstetrics; toxicology; air pollutions; biomarker; doses; embryonic neurogenesis; gamma-amino butyric acid receptor; gene expression patterns; mercury toxicity; mouse brain microarray dataset; water pollution; Bioinformatics; Biomarkers; Chemicals; Computational biology; Embryo; Gene expression; Mice; Neurotransmitters; Organisms; Pediatrics;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Science & Engineering Conference, 2009. BSEC 2009. First Annual ORNL

Conference_Location

Oak Ridge, TN

Print_ISBN

978-1-4244-3837-2

Type

conf

DOI

10.1109/BSEC.2009.5090491

Filename

5090491