Title :
Assessing the binding mode of ligands to DNA by time resolved fluorescence
Author :
Nardo, L. ; Bondani, M. ; Andreoni, A.
Author_Institution :
Insubria Univ., Como
Abstract :
Being able to determine the binding mode of a ligand to DNA, typically base intercalation (BI) or minor groove binding (MGB), is critical to determine the ligand therapeutic effects. Still, drug designers can only gain such information by means of indirect, complicated and very expensive methods.
Keywords :
DNA; binding energy; fluorescence; time resolved spectroscopy; DNA; base intercalation; ligand binding mode; ligand therapeutic effects; minor groove binding; time resolved fluorescence; Bismuth; Bonding; DNA; Drugs; Fluorescence; Laboratories; Laser excitation; Laser stability; Sequences; Ultrafast optics;
Conference_Titel :
Lasers and Electro-Optics, 2007 and the International Quantum Electronics Conference. CLEOE-IQEC 2007. European Conference on
Conference_Location :
Munich
Print_ISBN :
978-1-4244-0931-0
Electronic_ISBN :
978-1-4244-0931-0
DOI :
10.1109/CLEOE-IQEC.2007.4386659
