DocumentCode :
2167640
Title :
Assessing the binding mode of ligands to DNA by time resolved fluorescence
Author :
Nardo, L. ; Bondani, M. ; Andreoni, A.
Author_Institution :
Insubria Univ., Como
fYear :
2007
fDate :
17-22 June 2007
Firstpage :
1
Lastpage :
1
Abstract :
Being able to determine the binding mode of a ligand to DNA, typically base intercalation (BI) or minor groove binding (MGB), is critical to determine the ligand therapeutic effects. Still, drug designers can only gain such information by means of indirect, complicated and very expensive methods.
Keywords :
DNA; binding energy; fluorescence; time resolved spectroscopy; DNA; base intercalation; ligand binding mode; ligand therapeutic effects; minor groove binding; time resolved fluorescence; Bismuth; Bonding; DNA; Drugs; Fluorescence; Laboratories; Laser excitation; Laser stability; Sequences; Ultrafast optics;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Lasers and Electro-Optics, 2007 and the International Quantum Electronics Conference. CLEOE-IQEC 2007. European Conference on
Conference_Location :
Munich
Print_ISBN :
978-1-4244-0931-0
Electronic_ISBN :
978-1-4244-0931-0
Type :
conf
DOI :
10.1109/CLEOE-IQEC.2007.4386659
Filename :
4386659
Link To Document :
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