Title :
Functionalized gold nanoparticles for drug delivery
Author :
Coelho, S.C. ; Rocha, S. ; Pereira, M.C. ; Coelho, M.A.N. ; Juzenas, P.
Author_Institution :
Dept. of Chem. Eng., Univ. of Porto, Porto, Portugal
Abstract :
Gold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug activity and the anticancer effects in human prostate cancer cells (Du-145) were evaluated. It was observed that gold nanoparticles, with small diameters (24 nm), at concentrations of 0.1 nM are not toxic for Du-145 cells. Finally, nanoparticle parameters were discussed and new ideas are proposed to optimize the anticancer properties of conjugated gold nanoparticles leading to a better delivery of the drug, minimizing the side effects.
Keywords :
cancer; cellular biophysics; drug delivery systems; drugs; gold; nanomedicine; nanoparticles; radiation therapy; tumours; Au; BTZ; Du-145 cell; X-ray radiation; anticancer drug delivery; anticancer effects; anticancer properties; biological applications; cancer diagnosis; cancer therapy; drug activity; gold nanoparticles; human prostate cancer cells; nanoparticle parameters; proteasome inhibitor; size 24 nm; treatment efficacy; tumor eradication; Chemicals; Drugs; Lead; Nanobioscience; Nanoparticles; Du-145 cells; anticancer drug; cancer therapy; pegylated gold nanoparticles; prostate cancer cells;
Conference_Titel :
Bioengineering (ENBENG), 2013 IEEE 3rd Portuguese Meeting in
Conference_Location :
Braga
Print_ISBN :
978-1-4673-4859-1
DOI :
10.1109/ENBENG.2013.6518389
