Effect of the normalization template in statistical parametric mapping of PET scans

Author

Gispert, J.D. ; Pascau, J. ; Reig, S. ; Martinez, R. ; Molina, V. ; Desco, M.

Author_Institution

Med. lma ng Lab., Hosp. Universitario "Gregorio Maranon", Madrid, Spain

fYear

2002

fDate

2002

Firstpage

851

Lastpage

854

Abstract

The standard template provided with the statistical software package SPM´99 was originally developed for ¹⁵O-H₂O PET scans in resting condition with eyes closed. This template is commonly applied regardless of the tracer actually used in the scans being analyzed. This work studies the effect of three different normalization templates in the outcome of the statistical analyses of PET scans, as compared to a reference normalization. Results show that the use of the standard template in adverse conditions-different tracer, different cerebral condition-may introduce errors in the interpretation of the results of the statistical analysis.

Keywords

brain; medical image processing; positron emission tomography; statistical analysis; ¹⁵O-H₂O PET scans; H₂O; cerebral condition; interpretation errors; medical diagnostic imaging; normalization template effect; nuclear medicine; reference normalization; results interpretation analysis; statistical parametric mapping; statistical software package SPM´99; Biomedical imaging; Eyes; Hospitals; Laboratories; Magnetic resonance imaging; Positron emission tomography; Protocols; Psychiatry; Scanning probe microscopy; Statistical analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on

Print_ISBN

0-7803-7584-X

Type

conf

DOI

10.1109/ISBI.2002.1029393

Filename

1029393