Robust Control for cultivation of microorganisms in a high density fed-batch bioreactor

Author

Rodriguez, Abraham E. ; Torres Munoz, Jorge Antonio ; Luna, Ricardo ; Perez Correa, Jose Ricardo ; Dominguez Bocanegra, A.R. ; Sira Ramirez, Hebert ; Castro, R.

Author_Institution

Dept. de Control Automatico, CINVESTAV, Mexico City, Mexico

Volume

13

Issue

6

fYear

2015

fDate

Jun-15

Firstpage

1927

Lastpage

1933

Abstract

In this paper a nonlinear algorithm for adaptive control of a fed-batch bioreactor for high density cultures is proposed. The control of these processes is difficult due to parameter variations and process disturbances. The control scheme is based on a reduced model used to estimate the uncertainties with adaptive techniques. Convergence of estimated biomass to a desired neighborhood was proved based on the reduced model. The good performance of the control scheme was verified with full model simulations of the bioreactor simulations.

Keywords

adaptive control; bioreactors; microorganisms; nonlinear control systems; renewable materials; robust control; simulation; adaptive control; biomass; bioreactor simulations; cultivation; fed-batch bioreactor; high density cultures; microorganisms; nonlinear algorithm; robust control; Adaptation models; Adaptive control; Biological system modeling; Process control; Robust control; Robustness; Silicon compounds; Overflow metabolism; adaptive control; nonlinear control; yeast;

fLanguage

English

Journal_Title

Latin America Transactions, IEEE (Revista IEEE America Latina)

Publisher

ieee

ISSN

1548-0992

Type

jour

DOI

10.1109/TLA.2015.7164219

Filename

7164219