Synthesis of beta-Tricalciumphosphate Powder through Aqueous Precipitation Method

In the present study, we investigated the synthesis conditions and the cytocompatibility of single phase beta-tricalciumphosphate (beta-TCP) powder in order to And a very strict regulation of synthesis parameters. The precursors through aqueous precipitation methods were synthesized under several different conditions like reaction pH (3.5~9) and temperature (23~80degC) and flowing nitrogen or not and Ca/P ratio (=1.41 or 1.50) of initial reagents. Eight groups of the powders were obtained after the precursor being sintered at 1100degC and characterized by X-ray diffraction and four groups of single phase beta-TCP powders were studied in cytotoxicity assay. The experimental data indicate that single phase and cytocompatible beta-TCP powder can be obtained under the reaction condition with the low pH values (pH = 4~7), high temperature (50~70degC), flowing nitrogen and strict Ca/P ratio of initial reagents (Ca/P = 1.50).