Title :
Characterisation of chlorpromazine binding to lipid bilayer membranes
Author :
Nussio, Matthew R. ; Sykes, Matthew J. ; Miners, John O. ; Shapter, Joseph G.
Author_Institution :
Sch. of Chem., Phys. & Earth Sci., Flinders Univ., Adelaide, SA
Abstract :
With the aid of atomic force microscopy (AFM) and surface plasmon resonance (SPR), the interaction of chlorpromazine (CPZ) with phosphatidylcholine bilayer membranes was investigated. The interaction of CPZ had inherent effects on the transition temperature (TM), and hence, fluidity of DMPC phospholipid membranes. It was discovered that CPZ intercalates within the membrane bilayers to form a drug/phospholipid complex.
Keywords :
atomic force microscopy; drugs; lipid bilayers; surface plasmon resonance; atomic force microscopy; chlorpromazine binding; drug/phospholipid complex; lipid bilayer membranes; phosphatidylcholine bilayer membranes; phospholipid membranes; surface plasmon resonance; transition temperature; Atomic force microscopy; Biomembranes; Biosensors; Drugs; Instruments; Lipidomics; Plasmons; Proteins; Resonance; Temperature;
Conference_Titel :
Nanoscience and Nanotechnology, 2006. ICONN '06. International Conference on
Conference_Location :
Brisbane, Qld.
Print_ISBN :
1-4244-0453-3
Electronic_ISBN :
1-4244-0453-3
DOI :
10.1109/ICONN.2006.340603
