Network modeling of epileptic seizure genesis in hippocampus

The aim of this paper is to introduce an epileptic seizure model to predict how the whole dynamic of neural firing evolves with a changing in the ratio of inhibitory to excitatory synapses in a network of definite ensemble with random connections. The model is proposed for hippocampus network which is the focus of seizure in temporal lobe epilepsy. As it was proven experimentally, strong neuronal excitatory connectivity with weak inhibitory synapses lead to hyperexcitability and hypersynchronous firing of neurons. Simulation of this hallmark throughout this paper shows a transition from asynchronized firing to synchronized bursting behavior which is confirmed by synchronization measure delta.