Biomedical applications of enhanced backscattering spectroscopy

Author

Rogers, Jeremy D. ; Mutyal, Nikhil ; Radosevich, Andrew ; Turzhitsky, Vladimir ; Roy, Hemant ; Backman, Vadim

Author_Institution

Northwestern Univ., Evanston, IL, USA

fYear

2011

fDate

1-6 May 2011

Firstpage

1

Lastpage

2

Abstract

Enhanced Backscattering Spectroscopy enables minimally invasive measurement of optical properties of biological tissues by characterizing the shape of backscattered light in both angle and spectrum. The peak in scattering intensity in the retroreflection direction depends on the scattering properties of a random medium including mean free path, anisotropy, and even higher order characteristics such as mass fractal dimension. These properties are shown to be significant markers of risk in gastrointestinal cancers. Miniaturization of the technology with development of a fiber optic probe and supporting instrumentation enables in vivo clinical studies of risk stratification.

Keywords

bio-optics; biological tissues; biomedical measurement; cancer; cellular biophysics; health and safety; backscattered light; biological tissues; biomedical applications; enhanced backscattering spectroscopy; fiber optic probe; gastrointestinal cancers; in vivo clinical studies; invasive measurement; mass fractal dimension; mean free path; optical properties; retroreflection direction; risk stratification; scattering intensity; scattering properties; Backscatter; Biomedical optical imaging; Optical imaging; Optical scattering; Probes; Shape;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics (CLEO), 2011 Conference on

Conference_Location

Baltimore, MD

Print_ISBN

978-1-4577-1223-4

Type

conf

Filename

5950049