Mathematical modeling of nonlinear coupling mechanisms of gastric slow wave propagation and its SIMULINK simulation for investigating gastric dysrhythmia and pacing

Author

Wang, Z.S. ; Chen, JDZ

Author_Institution

GI Div., Texas Univ., Galveston, TX, USA

fYear

2000

fDate

2000

Firstpage

89

Lastpage

94

Abstract

Gastric electrical activity controls gastric peristalsis and plays an important role in the digestive process of the stomach. Gastric dysrhythmia has been reported to be associated with gastric functional diseases. The aim of this paper is to understand possible mechanisms involved in the generation of gastric electrical dysrhythmia and the feasibility of gastric pacing for the normalization of gastric dysrhythmia. First, a mathematical model is established to stimulate normal and abnormal gastric electrical activities, and then its SIMULINK circuit implementation is applied to simulate the effect of gastric pacing for the normalization of gastric dysrhythmia

Keywords

bioelectric phenomena; digital simulation; diseases; medical computing; physiological models; wave propagation; SIMULINK simulation; circuit implementation; digestive process; gastric dysrhythmia; gastric electrical activity; gastric functional diseases; gastric pacing; gastric peristalsis; gastric slow-wave propagation; mathematical modeling; nonlinear coupling mechanisms; normalization; stomach; Calcium; Couplings; Extracellular; Integrated circuit modeling; Mathematical model; Medical simulation; Muscles; Pacemakers; Read only memory; Stomach;

fLanguage

English

Publisher

ieee

Conference_Titel

Computer-Based Medical Systems, 2000. CBMS 2000. Proceedings. 13th IEEE Symposium on

Conference_Location

Houston, TX

ISSN

1063-7125

Print_ISBN

0-7695-0484-1

Type

conf

DOI

10.1109/CBMS.2000.856884

Filename

856884