Title :
Retroactivity attenuation in transcriptional networks: Design and analysis of an insulation device
Author :
Vecchio, Domitilla Del ; Jayanthi, Shridhar
Author_Institution :
Dept. of Electr. Eng. & Comput. Sci., Univ. of Michigan, Ann Arbor, MI, USA
Abstract :
Retroactivity is a phenomenon that changes the desired input/output response of a system when it is connected to ¿downstream¿ systems. Transcriptional networks are not immune to this phenomenon. In this paper, we propose a phosphorylation-based design for a bio-molecular system that acts as an insulator between its upstream systems and its downstream ones in a transcriptional network. Performing singular perturbation analysis, we mathematically show that such a design attenuates retroactivity. Stochastic simulations are run to analyze the robustness of the proposed device to biological noise and to highlight design tradeoffs.
Keywords :
biomolecular electronics; insulation; singularly perturbed systems; stochastic processes; biological noise; biomolecular system; desired input-output response; downstream systems; highlight design tradeoffs; insulation device analysis; insulation device design; phosphorylation-based design; retroactivity attenuation; singular perturbation analysis; stochastic simulation; transcriptional networks; upstream systems; Analytical models; Attenuation; Biological system modeling; Biological systems; Control systems; Immune system; Insulation; Noise robustness; Performance analysis; Stochastic resonance;
Conference_Titel :
Decision and Control, 2008. CDC 2008. 47th IEEE Conference on
Conference_Location :
Cancun
Print_ISBN :
978-1-4244-3123-6
Electronic_ISBN :
0191-2216
DOI :
10.1109/CDC.2008.4739037
