DocumentCode
2248307
Title
Metabolic networks analysis using convex optimization
Author
Julius, A. Agung ; Imielinski, Marcin ; Pappas, George J.
Author_Institution
Dept. Electr. & Syst. Eng., Univ. of Pennsylvania, Philadelphia, PA, USA
fYear
2008
fDate
9-11 Dec. 2008
Firstpage
762
Lastpage
767
Abstract
Metabolic networks map the biochemical reactions in a living cell to the flow of various chemical substances in the cell, which are called metabolites. A standard model of a metabolic network is given as a linear map from the reaction rates to the change in metabolites concentrations. We study two problems related to the analysis of metabolic networks, the minimal network problem and the minimal knockout problem.
Keywords
optimisation; biochemical reactions; chemical substances; convex optimization; metabolic networks analysis; metabolites concentrations; minimal knockout problem; minimal network problem; Biochemistry; Bioinformatics; Biological system modeling; Cells (biology); Cellular networks; Genomics; Organisms; Production; Steady-state; Systems biology;
fLanguage
English
Publisher
ieee
Conference_Titel
Decision and Control, 2008. CDC 2008. 47th IEEE Conference on
Conference_Location
Cancun
ISSN
0191-2216
Print_ISBN
978-1-4244-3123-6
Electronic_ISBN
0191-2216
Type
conf
DOI
10.1109/CDC.2008.4739111
Filename
4739111
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