Title :
Optical tomographic imaging of tumor response to anti-angiogenic drugs in small animals
Author :
Flexman, M.L. ; Hernandez, S.L. ; Huang, J. ; Johung, T.J. ; Kim, H.K. ; Lee, J. ; Vlachos, F. ; Yamashiro, D.J. ; Kandel, J. ; Hielscher, A.H.
Author_Institution :
Dept. of Biomed. Eng., Columbia Univ., New York, NY, USA
Abstract :
Using diffuse optical tomography we have imaged early vascular responses to anti-angiogenic treatments in a small animal tumor model. Images acquired from 1 to 7 days after drug administration show measurable changes in hemoglobin concentration. There are observable differences between mice treated with anti-angiogenic drugs and mice that receive a placebo treatment.
Keywords :
biochemistry; blood vessels; drugs; molecular biophysics; optical tomography; proteins; tumours; anti-angiogenic drugs; anti-angiogenic treatments; diffuse optical tomography; early vascular responses; hemoglobin concentration; mice; placebo treatment; small animals; tumor model; Animals; Biomedical optical imaging; Drugs; Engine cylinders; Mice; Neoplasms; Optical imaging; Optical noise; Optical scattering; Tomography;
Conference_Titel :
Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast
Conference_Location :
New York, NY
Print_ISBN :
978-1-4244-6879-9
DOI :
10.1109/NEBC.2010.5458151
