Title :
Monitoring of anti-angiogenic drug response with dynamic fluorescence imaging
Author :
Lee, Jonghwan ; Pöschinger, Thomas ; Hernandez, Sonia L. ; Huang, Jianzhong ; Johung, Tessa ; Kandel, Jessica ; Yamashiro, Darrell J. ; Hielscher, Andreas H.
Author_Institution :
Dept. of Biomed. Eng., Columbia Univ., New York, NY, USA
Abstract :
We present the results of a study in which we monitored anti-angiogenic therapy response in a mouse cancer model with in-vivo dynamic fluorescence imaging. In the experiments indocyanine green (ICG) was used as a fluorescent optical contrast agent and its time-dependent uptake and washout before and after the administration of bevacizumab was recorded. We found that compared with other organs, tumors showed a noticeable difference in ICG kinetics after treatment.
Keywords :
biological organs; bioluminescence; biomedical optical imaging; cancer; cellular biophysics; drugs; tumours; anti-angiogenic drug response; dynamic fluorescence imaging; fluorescent optical contrast; indocyanine green; mouse cancer model; tumors; Cancer; Drugs; Fluorescence; Kinetic theory; Medical treatment; Mice; Monitoring; Neoplasms; Optical imaging; Optical recording;
Conference_Titel :
Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast
Conference_Location :
New York, NY
Print_ISBN :
978-1-4244-6879-9
DOI :
10.1109/NEBC.2010.5458158
