Title :
In silicon evaluation of nanoparticle cell interaction via human TLR3
Author :
Maggi, Norbert ; Arrigo, Patrizio ; Ruggiero, Carmelina
Author_Institution :
Dept. of Commun., Comput. & Syst. Sci., Univ. of Genoa, Genoa, Italy
Abstract :
Nanomaterials are becoming widely used in nanomedicine for pharmaceutical applications. This paper addresses the analysis of the possible cytotoxic effects of nanostructured materials. Specifically, the behavior of some nanoparticles against Toll-like receptors (TLRs), a class of proteins that play a key role in the innate immune system, is considered by docking analysis. The results show that the nanoparticles that have been considered have the potential to affect the immune system via TLRs.
Keywords :
biomedical materials; cellular biophysics; drugs; nanomedicine; nanoparticles; proteins; toxicology; Toll-like receptors; cytotoxic effects; docking analysis; human TLR3; nanomaterials; nanomedicine; nanoparticle cell interaction; nanostructured materials; pharmaceuticals;
Conference_Titel :
Nanotechnology (IEEE-NANO), 2010 10th IEEE Conference on
Conference_Location :
Seoul
Print_ISBN :
978-1-4244-7033-4
Electronic_ISBN :
1944-9399
DOI :
10.1109/NANO.2010.5697852
