Integration of macro circulation and micro hemodynamics in the human body for physiological diagnosis and simulation

The purpose of this study is to describe a method of how physiological simulation and diagnosis for the cardiovascular system can be achieved in clinical use. The circulatory system model aims to represent various changes or diseases based on experimental measurements. In respect with some designed levels, the circulatory system could be modeled into a target granularity of sizes, resolutions, or timescales. The macro model contains a wide range of physiological information for various subsystems within the whole body, but it is impossible to be detailed into small time units for time-dependent variables. Whereas, the micro model enables to analyze microscopic behavior only for a single subsystem, because the extrafunctions of the whole body are omitted. Therefore, the proposed physiological simulation method integrates macro circulatory and micro cardiovascular system models, so that long-term macroscopic body conditions and short-term microscopic blood flow could be concurrently simulated.