Title :
Ventricular wall bulge and oxygen consumption in stunned myocardium modeling
Author :
Wang, Jia-Jung ; Drzewiecki, Gary ; Li, John K-J.
Author_Institution :
Dept. of Biomed. Eng., Rutgers Univ., Piscataway, NJ, USA
Abstract :
Reversible dysfunction of the myocardium after a single or multiple episodes of coronary artery occlusion is termed myocardial stunning. In this study, the hypothesis that stunning could best be represented by an increase in resting length and a concomitant decrease in maximum available muscle force in the stunned region was examined by means of a mathematical model. Hemodynamic measures were found to be similar to those of experiment data, thus supporting the model validity. Oxygen consumption was found to slightly increase as paradoxically observed in experiments. The model explains this as increased heat production while external work decreases with stunning
Keywords :
biomechanics; cardiology; haemodynamics; muscle; oxygen; physiological models; O2; coronary artery occlusion; external work; hemodynamic measures; increased heat production; mathematical model; maximum available muscle force decrease; model validity; myocardial stunning; oxygen consumption; resting length increase; stunned myocardium modeling; ventricular wall bulge; Analog circuits; Arterial occlusion; Biomedical engineering; Cardiology; Laboratories; Mathematical model; Muscles; Myocardium; Oxygen; Shape control;
Conference_Titel :
Bioengineering Conference, 1995., Proceedings of the 1995 IEEE 21st Annual Northeast
Conference_Location :
Bar Harbor, ME
Print_ISBN :
0-7803-2692-X
DOI :
10.1109/NEBC.1995.513712
