Title :
Bioactive surface modification for neurite development
Author :
Potember, Richard S. ; Matsuzawa, Mieko ; Liesi, Päivi
Author_Institution :
Appl. Phys. Lab., Johns Hopkins Univ., Laurel, MD, USA
Abstract :
A combination of photolithographic and chemical techniques were used to prepare biologically active patterned substrates to guide the development of neurons in culture. A synthetic peptide, derived from the B2 chain of laminin was chemically attached to patterned silicon surfaces to promote the development and guidance of embryonic rat hippocampal neurons. On parallel lines, neurons developed a mature bipolar morphology. These modified surfaces may be an important element of future biosensors and neural prosthetic devices
Keywords :
biological techniques; cellular biophysics; neurophysiology; photolithography; substrates; Si; bioactive surface modification; biologically active patterned substrates; biosensors; embryonic rat hippocampal neurons; laminin B2 chain; mature bipolar morphology; neural prosthetic devices; neurite development; patterned silicon surfaces; synthetic peptide; Amino acids; Chemical elements; Chemical technology; Embryo; Laboratories; Neurons; Peptides; Physics; Substrates; Surface morphology;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.415174
