Title :
Analysis of the hot spots of coated pits in live cells
Author :
Deng, Jia ; Leung, Henry ; Elliott, Robert J. ; Wong, Stephen ; Zhou, Xiaobo
Author_Institution :
Calgary Univ., Calgary
Abstract :
Coated pits carry important information about plasma membrane and endosomes. They remove proteins and lipids from the plasma membrane and transport them to the endosomal compartment. It is of interest to get a thorough understanding of these pits. In this paper, we consider two kinds of proteins in coated pits: clathrin and AP-2. We propose a detection method to extract as many coated pits trajectories as possible. It is observed that we can predict whether or not a pit will appear at certain "hot spot" at a certain time.
Keywords :
biomembrane transport; lipid bilayers; molecular biophysics; proteins; AP-2 proteins; clathrin proteins; coated pits; endosomes; hot spots; lipids; live cells; plasma membrane; Biomedical engineering; Biomembranes; Educational institutions; Hospitals; Information analysis; Lipidomics; Motion pictures; Plasma transport processes; Proteins; Radiology;
Conference_Titel :
Life Science Systems and Applications Workshop, 2007. LISA 2007. IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4244-1813-8
Electronic_ISBN :
978-1-4244-1813-8
DOI :
10.1109/LSSA.2007.4400882
