A simple model of the chemical regulation of acid-base balance in blood

Author

Chiari, L. ; Avanzolini, G. ; Grandi, F. ; Gnudi, G.

Author_Institution

Dipartimento di Elettronica Inf. e Sistemistica, Bologna Univ., Italy

fYear

1994

fDate

1994

Firstpage

1025

Abstract

A simple model of the chemical acid-base regulation in blood is formulated and analysed. The model incorporates only two interacting buffers representing bicarbonate and non-bicarbonate (mainly hemoglobin and plasma proteins) buffers. The results obtained show that, in spite of its simplicity, this model represents accurately a large set of relationships between CO₂ concentration and partial pressure, pH, base excess (BE) within the physiological range of variables

Keywords

biocontrol; CO₂; CO₂ concentration; acid-base balance; base excess; bicarbonate buffers; blood; chemical acid-base regulation; chemical regulation; hemoglobin; interacting buffers; nonbicarbonate buffers; pH; partial pressure; physiological range of variables; plasma proteins; simple model; Blood; Chemical analysis; Control systems; Hydrogen; Medical control systems; Nonlinear equations; Plasma chemistry; Proteins; Respiratory system; Steady-state;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE

Conference_Location

Baltimore, MD

Print_ISBN

0-7803-2050-6

Type

conf

DOI

10.1109/IEMBS.1994.415307

Filename

415307