Simulation of ectopic activity induced by EADs in Purkinje fibers. Influence of Purkinje-muscle coupling

Author

Monserrat, M. ; Saiz, J. ; Ferrero, JM, Jr. ; Torres, V. ; Trenor, B. ; Ferrero, JM ; Thakor, NV

Author_Institution

L.I.B.-D.I.E., Univ. Politecnica de Valencia, Spain

fYear

1998

fDate

13-16 Sep 1998

Firstpage

181

Lastpage

184

Abstract

The purpose of this work was to study the influence of the Purkinje-Ventricular Junction (PVJ) on the ectopic activity generated in the ventricular muscle due to the generation of Early Afterdepolarizations (EADs) in Purkinje fibers. In the study, a mathematical model simulating the electrical activity of a Purkinje Fiber (PF) connected to a ventricular muscle fiber (VMF) has been used. Conditions that induce the generation of EADs have been introduced in the Purkinje cells. It has been observed that the ectopic activity arising in the VMF can consist of a single beat or of a rhythmic series of beats. Besides, depending on the conditions of generation of EADs applied, the existence of a certain uncoupling between the fibers can be critical or not to allow the development of ectopic activity

Keywords

bioelectric phenomena; cardiology; cellular biophysics; muscle; physiological models; Purkinje-muscle coupling; Purkinje-ventricular junction; cardiac electrophysiology; early afterdepolarizations; ectopic activity; ectopic activity simulation; mathematical model; rhythmic series; single beat; uncoupling between fibers; ventricular muscle fiber; Biomedical engineering; Biomembranes; Boundary conditions; Computational modeling; Delay; Equations; Heart rate variability; Mathematical model; Muscles; Numerical models;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1998

Conference_Location

Cleveland, OH

ISSN

0276-6547

Print_ISBN

0-7803-5200-9

Type

conf

DOI

10.1109/CIC.1998.731762

Filename

731762