Using 10–23 DNAzyme to solve simple 0–1 programming problem

10-23 DNAzyme can be used as a logical operation due to its amputation mRNA at the AU point. In this paper, a new DNA computing model using 10-23 DNAzyme was presented to solve 0-1 programming problem, which is an important problem in operation and has very widespread applications. Benefited from vast parallelism, extraordinary information density and easy manipulation of solution-based DNA computation, the designed model further simplified the read-out steps by DNAzyme. The result, verified by computer simulation, suggested the great potential of DNA computing on solving complex programming problems.