Title :
Regional delivery of oxygen and carbon dioxide in the microcirculation
Author :
Ye, Guo-Fan ; Jaron, Dov
Author_Institution :
Biomed. Eng. & Sci. Inst., Drexel Univ., Philadelphia, PA, USA
Abstract :
A partial pressure dependent metabolic mechanism was incorporated into our previous multicompartmental model for O2-CO2 coupled transport in the cat cerebral microcirculation-tissue system. The refined model predicts the distribution of O2 and CO2 concentrations and regional flux along the microcirculation under various hemodynamic and metabolic conditions. Our simulation indicates that capillaries are the main site for O2 as well as CO2 exchange in the microcirculation. This is in contrast with results from the Roth and Wade model suggesting precapillary preponderance of CO2 exchange
Keywords :
haemorheology; CO2; CO2 concentrations; O2; O2 concentrations; O2-CO2 coupled transport; capillaries; cat cerebral microcirculation-tissue system; hemodynamic conditions; metabolic conditions; microcirculation; multicompartmental model; partial pressure dependent metabolic mechanism; regional delivery; regional flux; Biochemistry; Biomedical engineering; Biomedical measurements; Blood; Carbon dioxide; Equations; Hemodynamics; Muscles; Oxygen; Predictive models;
Conference_Titel :
Engineering in Medicine and Biology Society, 1994. Engineering Advances: New Opportunities for Biomedical Engineers. Proceedings of the 16th Annual International Conference of the IEEE
Conference_Location :
Baltimore, MD
Print_ISBN :
0-7803-2050-6
DOI :
10.1109/IEMBS.1994.415375
