Effect of tDCS application on P300 potentials: A randomized, double blind placebo controlled study

In this paper, we report the results of a study on the post-intervention effects of applying anodal transcranial direct current stimulation (A-tDCS) on the intensity of P300 potentials. Each of the eight subjects were given both 15 minutes sham and 1.5 mA tDCS in randomized order, in two separate experiments separated by 1 week. The interventions were double blinded. Post-intervention EEG was then recorded after each experiment while subjects were asked to perform a spelling task based on the “odd ball paradigm”. Results show a 22% difference, in normalized signal power between tDCS and sham when recorded at 250ms-450ms with a paired t-test p value of 0.057.