Cytotoxicity of hydroxyapatite and morphology in composites with Ti

Author

Comin, Riccardo ; Reyna, L.A. ; Cid, M.P. ; Oldani, C.R. ; Salvatierra, N.A.

Author_Institution

Fac. de Cienc. Exactas Fisicas y Naturales, UNC, Cordoba, Argentina

Volume

11

Issue

1

fYear

2013

fDate

Feb. 2013

Firstpage

97

Lastpage

100

Abstract

Hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂ is the material used to improve osseointegration of implants in humans. Traditionally Ti-based implant is coated with hydroxyapatite, but this presents several problems such as, low fracture toughness of hydroxyapatite, generation of interfacial cracks during the deposition step and low adhesion ceramic /metal. Furthermore some studies reported that some excellent Ti¿HA bio-composites could be fabricated by the powder metallurgy (PM) technology. In present study it was investigate the cytotoxicity of coralline and bovine hydroxyapatite. Topography of Ti-HA composites obtained by powder metallurgy was evaluated by scanning electron microscopy. The results showed that HA samples analyzed did not affect cell viability. Furthermore, a good integration of HA to the matrix of Ti was observed by microscopy studies.

Keywords

adhesion; bioceramics; biomechanics; calcium compounds; fracture toughness; powder metallurgy; prosthetics; titanium; toxicology; Ca₁₀(PO₄)₆(OH)₂-Ti; adhesion; cell viability; cytotoxicity; fracture toughness; hydroxyapatite; implants; interfacial cracks; morphology; osseointegration; powder metallurgy; scanning electron microscopy; topography; Biology; ISO standards; Implants; Laboratories; Medical services; Microscopy; Powders; Hydroxyapatite; Ti-HA composites; biocompatibility; powder metallurgy;

fLanguage

English

Journal_Title

Latin America Transactions, IEEE (Revista IEEE America Latina)

Publisher

ieee

ISSN

1548-0992

Type

jour

DOI

10.1109/TLA.2013.6502785

Filename

6502785