Dispersion of refractoriness and unidirectional block in a model of ischemic myocardium

Author

Maglaveras, N. ; Van Capelle, FJL ; Allessie, M. ; Sahakian, A.V. ; Pappas, C. ; Strintzis, M.

Author_Institution

Aristotelian Univ. of Thessaloniki, Greece

fYear

1993

fDate

5-8 Sep 1993

Firstpage

663

Lastpage

666

Abstract

Ischemia effects on propagation characteristics are studied in a one-dimensional model of myocardium using the Luo-Rudy model. In particular the effects of changes in electrophysiologic parameters on propagation block, action potential duration and the effects of premature impulses in propagation characteristics around the border zone between normal and ischemic tissue are studied. It is shown that the direction of propagation coupled with changes in coupling resistance and resting membrane potential plays a dramatic role in altering propagation characteristics and action potential duration spatial distribution

Keywords

bioelectric potentials; cardiology; muscle; physiological models; Luo-Rudy model; action potential duration spatial distribution; coupling resistance; electrophysiologic parameters; ischemic myocardium model; premature impulses effects; propagation characteristics; propagation direction; refractoriness dispersion; resting membrane potential; unidirectional block; Biomembranes; Blood flow; Cells (biology); Conductivity; Difference equations; Extracellular; Finite difference methods; Injuries; Ischemic pain; Myocardium;

fLanguage

English

Publisher

ieee

Conference_Titel

Computers in Cardiology 1993, Proceedings.

Conference_Location

London

Print_ISBN

0-8186-5470-8

Type

conf

DOI

10.1109/CIC.1993.378315

Filename

378315