Microdosimetry applied to nanosecond pulsed electric fields: A comparison on a single cell between real and ideal waveforms

A microdosimetric analysis using ideal and real pulses was carried out in this paper. To perform this goal, authors employed an algorithm developed recently for nsPEF based on Laplace´s equation and able to take into account cell compartment dispersivity. A comparison between biphasic real and ideal waveforms was carried out. The ideal pulse induced the highest pore density efficiency, hence evidencing that a device optimization to avoid waveform degradation and losses has a fundamental impact on the performances of the delivered pulses at the single cell level.