Title :
Association of Chinese medicine physiquein susceptibility to diabetic nephropathy and TGF-β 1 (T869C) gene polymorphism
Author :
Mou, Xin ; Liu, Wenhong
Author_Institution :
Hangzhou Red Cross Hosp., Hangzhou China, Hangzhou, China
Abstract :
To investigate influence of administration of Shenxiao decoction on the expression of NADPH oxidase,renal function and structure in diabetic nephropathy rat.Method:Experimental diabetic nephropathy model was induced by nephrectomy combined with streptozotocin (STZ) injection in sprague-dawley rat. Shenxiao decoction and Irbesartan were orally administrated respectively for 16 weeks.and the expression of NADPH oxidase subunit p22hox was measured. 24 h urine protein excretion (Upro) and renal pathological changes were observed.Results: The ratio of urinary protein excretion, the renal protein expression of p22phox were significantly increased in diabetic nephropathy rat, and the renal protein expression of Cu-Zn SOD were significantly decreased in diabetic nephropathy rat.Shenxiao decoction and Irbesartan treatment can significantly prevent these changes in diabetic nephropathy rat. Conclusion: Shenxiao decoction treatment can significantly decrease the renal oxidative stress level, lessen the renal oxidative damage, and produce the protection of kidney in diabetic nephropathy rat.
Keywords :
biochemistry; cellular biophysics; diseases; enzymes; genetics; molecular biophysics; patient treatment; polymorphism; Chinese medicine physiquein susceptibility; Irbesartan treatment; NADPH oxidase subunit; Shenxiao decoction; T869C gene polymorphism; TGF-β 1; diabetic nephropathy model; kidney; nephrectomy; rat; renal function; renal oxidative damage; renal oxidative stress level; renal pathological changes; renal protein expression; sprague-dawley rat; streptozotocin injection; time 16 week; time 24 h; urine protein excretion; DNA; Diabetes; Diseases; Kidney; Logistics; Proteins; System-on-a-chip; Irbesartan; NADPH; Shenxiao decoction; diabetic nephropathy;
Conference_Titel :
Remote Sensing, Environment and Transportation Engineering (RSETE), 2011 International Conference on
Conference_Location :
Nanjing
Print_ISBN :
978-1-4244-9172-8
DOI :
10.1109/RSETE.2011.5965881
