Optical tweezers: Getting a handle on the microscopic biological world

Author

Sonek, G.J. ; Wright, W.H. ; Berns, M.W.

Author_Institution

Dept. of Electr. & Comput. Eng., California Univ., Irvine, CA, USA

fYear

1993

fDate

15-18 Nov 1993

Firstpage

234

Lastpage

235

Abstract

Optical tweezers are an important tool for use as non-contact micromanipulators of biological cells and organisms. The ability to apply optical forces in the pN regime means that optical tweezers can also be used as transducers of the fundamental forces responsible for cell locomotion, cell adhesion, and intracellular transport. Herein, we describe our recent results in modeling and measuring the optical trapping forces that are applied to dielectric microsphere and biological sperm cell samples

Keywords

biological effects of laser radiation; biological techniques; cellular biophysics; particle size; radiation pressure; biological cells; biological sperm cell samples; cell adhesion; cell locomotion; dielectric microsphere; fundamental forces; intracellular transport; microscopic biological world; noncontact micromanipulators; optical forces; optical trapping forces; optical tweezers; organisms; pN regime; transducers; Adhesives; Biological cells; Biological system modeling; Biomedical optical imaging; Dielectric measurements; Force measurement; Micromanipulators; Optical microscopy; Organisms; Transducers;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics Society Annual Meeting, 1993. LEOS '93 Conference Proceedings. IEEE

Conference_Location

San Jose, CA

Print_ISBN

0-7803-1263-5

Type

conf

DOI

10.1109/LEOS.1993.379024

Filename

379024