Title :
Robustness of inverse perturbation for discrete event control
Author :
Bouaynaya, Nidhal ; Shterenberg, Roman ; Schonfeld, Dan
Author_Institution :
Dept. of Syst. Eng., Univ. of Arkansas at Little Rock, Little Rock, AR, USA
fDate :
Aug. 30 2011-Sept. 3 2011
Abstract :
We study the robustness of the inverse perturbation solution in discrete-time systems modeled by homogeneous Markov chains. We cast the optimal inverse perturbation control as a strictly convex optimization problem, which admits a unique global solution. We show that the optimal inverse perturbation control is robust to estimation errors in the original network. The derived results are applied to the Human melanoma gene regulatory network, where the aim is to force the network to converge to a desired steady-state distribution of gene regulation.
Keywords :
Markov processes; biocontrol; convex programming; discrete event systems; discrete time systems; genetics; optimal control; perturbation techniques; robust control; discrete event control; discrete-time system; homogeneous Markov chains; human melanoma gene regulatory network; inverse perturbation solution; optimal inverse perturbation control; robustness; steady-state distribution; strictly convex optimization problem; Convex functions; Estimation error; Humans; Malignant tumors; Markov processes; Robustness; Steady-state; Finite Markov chains; Inverse perturbation; Perturbation theory; robustness; stability; Computer Simulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Markov Chains; Melanoma; Models, Biological; Models, Statistical; Neoplasm Proteins;
Conference_Titel :
Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4121-1
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2011.6090674