Title :
Model-based analysis of deep brain stimulation of the thalamus
Author :
McIntyre, Cameron C. ; Grill, Warren M. ; Sherman, David L. ; Thakor, Nitish V.
Author_Institution :
Dept. of Biomed. Eng., Johns Hopkins Univ. Sch. of Med., Baltimore, MD, USA
Abstract :
High-frequency (∼150 Hz) deep brain stimulation (DBS) represents a rapidly emerging therapy in the treatment of medically refractory movement disorders. However, fundamental questions remain about the effects of DBS at both the single cell and network levels. We determined the effects of high frequency stimulation of the thalamus using the combination of a finite element model of the DBS electrode, a multi-compartment cable model of a thalamocortical relay neuron, and a large-scale neural network model of the thalamocortical system. The results show that DBS has an excitatory effect on neural elements near the electrode, and this thalamic excitation results in increased cortical activity. This study supports the hypothesis of excitation-induced changes in network activity as a therapeutic mechanism of DBS.
Keywords :
bioelectric phenomena; biomechanics; brain models; cellular biophysics; finite element analysis; neural nets; neurophysiology; 150 Hz; deep brain stimulation; excitatory effect; increased cortical activity; medically refractory movement disorders; model-based analysis; network level; neural elements; rapidly emerging therapy; single cell level; thalamocortical system; thalamus; therapeutic mechanism; Biomedical electrodes; Brain modeling; Brain stimulation; Finite element methods; Frequency; Large-scale systems; Medical treatment; Neurons; Relays; Satellite broadcasting;
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
Print_ISBN :
0-7803-7612-9
DOI :
10.1109/IEMBS.2002.1053160
