Combination of fluorescence and reflectance spectroscopy for in vivo detection of cervical pre-cancers

Author

Chang, Sung K. ; Mirabal, Yvette N. ; Atkinson, E. Neely ; Malpica, Anais ; Follen, Michele ; Richards-Kortum, R.

Author_Institution

Dept. of Biomed. Eng., Univ. of Texas, Austin, TX, USA

Volume

3

fYear

2002

fDate

23-26 Oct. 2002

Firstpage

2265

Abstract

The goal of this study is to identify fluorescence excitation wavelengths and reflectance source-detector separations that are significant for diagnosis of cervical pre-cancers. Measurements from fluorescence and reflectance spectroscopy were searched exhaustively using Mahalanobis distance based classification. Fluorescence excitation wavelengths at 340 nm, 350 nm and 410 nm and reflectance source-detector separation of 250 μm appear significant for discriminating a pair of diagnostic classes.

Keywords

bio-optics; cancer; gynaecology; patient diagnosis; 250 micron; 340 nm; 350 nm; 410 nm; Mahalanobis distance based classification; cervical precancers; diagnostic classes pair discrimination; fluorescence excitation wavelengths; in vivo detection; medical diagnostic technique; reflectance source-detector separations; reflectance spectroscopy; Biomedical optical imaging; Cervical cancer; Fluorescence; In vivo; Optical refraction; Optical scattering; Optical sensors; Reflectivity; Spectroscopy; Wavelength measurement;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint

ISSN

1094-687X

Print_ISBN

0-7803-7612-9

Type

conf

DOI

10.1109/IEMBS.2002.1053274

Filename

1053274