Title :
Towards bio-nanotransistors for electrical DNA sensing
Author :
Faglia, G. ; Baratto, C. ; Comini, E. ; Ferroni, M. ; Sberveglieri, G. ; Flamini, A. ; Andreano, G. ; Cellai, L. ; Marrazza, G. ; Nannini, A. ; Pennelli, G. ; Piotto, M.
Author_Institution :
Univ. di Brescia, Brescia
Abstract :
We report on the innovative electrical detection of biological binding, based on a thin metal oxide (MOX) film as channel for a field effect transistor. The working principle relies on modulation of a MOX space charge region (SCR) instead of an enriched/depleted Si channel like in chem-FETs. The feasibility of the working principle was at first demonstrated by pH measurement in liquid. Afterwards we implemented a reliable protocol for the immobilization of ODNs and for the electrical detection of their hybridization. Work is in progress to scale MOX down to nanosized nanowire.
Keywords :
biosensors; field effect transistors; macromolecules; nanoelectronics; space charge; bionanotransistors; electrical DNA sensing; field effect transistor; pH measurement; space charge region; thin metal oxide film; Absorption; Biosensors; DNA; Event detection; Fluorescence; Molecular biophysics; Nanobioscience; Probes; Sputtering; Thin film sensors;
Conference_Titel :
Sensors, 2006. 5th IEEE Conference on
Conference_Location :
Daegu
Print_ISBN :
1-4244-0375-8
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2007.355483
