Changes of skin temperature of parts of the body and serum asymmetric dimethylarginine (ADMA) in type-2 diabetes mellitus Indian patients

In India, number of people with type 2 Diabetes Mellitus (DM) would be 87 million by the year 2030. DM disturbs autonomic regulation of skin micro-circulation, and causes decrease in resting blood flows through the skin. The skin blood flow has a major effect on its temperature. The aim of the study was to evaluate changes of skin temperature of all parts of the body and serum asymmetric dimethylarginine, ADMA (μmol/L) in type-2 DM Indian patients. Group-I: Normal (n=17; M/F: 10/15, mean±SD= 43.2±9.4 years); Group-II: Type-2 DM without cardiovascular (CV) complications (n=15; M/F: 10/7, mean±SD= 46.3 ± 14.0 years); Thermograms of all parts of the body were acquired using a non-contact infrared (IR) thermography camera (ThermaCAM T400, FLIR Systems, Sweden). Blood parameters and thyroid hormone were measured biochemically. Indian diabetic risk score (IDRS) was calculated for each subject. In type-2 DM patients without CV group (n=15), there was a statistically significant (p=0.01) negative correlations between HbA_1c and skin temperature of eye and nose (r= -0.57 and r= -0.55 respectively). ADMA was correlated significantly (p=0.01) with HbA_1c (r=0.65) and estimated average glucose, eAG (r=0.63). In normal subjects, mean minimum and maximum values of skin temperatures were observed at posterior side of sole (26.89°C) and ear (36.85°C) respectively. In type-2 DM without CV, mean values of skin temperature in different parts of the body from head to toe were lesser than those values in control group; but this decreases were statistically significant in nose (32.66 Vs 33.99°C, p=0.024) as well as in tibia (32.78 Vs 33.13°C, p=0.036) regions.