DocumentCode :
2501104
Title :
Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging: Normal Volunteers Examined During Normal Breathing and Hyperventilation
Author :
Wirestam, Ronnie ; Engvall, Christian ; Ryding, Erik ; Holtas, S. ; Stahlberg, F. ; Reinstrup, Peter
Author_Institution :
Depts. of Med. Radiat. Phys., Anesthesiology & Intensive Care, Lund Univ., Lund, Sweden
fYear :
2009
fDate :
11-13 June 2009
Firstpage :
1
Lastpage :
4
Abstract :
Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 plusmn 19 ml/(min 100 g) during normal breathing and 52 plusmn 7.9 ml/(min 100 g) during hyperventilation (mean plusmn SD, n = 8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.
Keywords :
biomedical MRI; blood flow measurement; brain; magnetic susceptibility; pneumodynamics; DSC-MRI; cerebral blood flow; cerebral perfusion; dynamic susceptibility contrast magnetic resonance imaging; hyperventilation; hypocapnia; Biomedical imaging; Blood flow; Hospitals; Magnetic resonance imaging; Magnetic susceptibility; Medical diagnostic imaging; Neurophysiology; Physics; Radiation detectors; Radiology;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
Type :
conf
DOI :
10.1109/ICBBE.2009.5162484
Filename :
5162484
Link To Document :
بازگشت