Title :
A MULTI-SCALE METHOD FOR BIOLUMINESCENCE TOMOGRAPHY USING MULTIPLE TYPES OF A PRIORI INFORMATION
Author :
Lv, Yujie ; Tian, Jie ; Yang, Wei ; Qin, Chenghu ; Cong, Wenxiang ; Wang, Ge
Author_Institution :
Inst. of Autom., Chinese Acad. of Sci., Beijing
Abstract :
Bioluminescence tomography (BLT) is a novel in vivo technique which may reveal the molecular and cellular activity at the whole-body level in small animal studies. In order to reconstruct bioluminescence sources accurately, it is necessary to incorporate all types of a priori information available and develop novel reconstruction algorithms. In this paper, a multi-scale method is proposed for BLT based on adaptive finite element analysis. Specifically, multiple constraints, including multi-spectral measurements, anatomical and optical knowledge, are imposed to deal with the solution non-uniqueness of BLT. Also, adaptive finite element meshing and permissible source region refinement are utilized to help improve the reconstruction quality and speed. Finally, with the micro-MRI based virtual mouse phantom (MOBY) and the Monte Carlo based synthetic data, the feasibility and effectiveness of this BLT approach is demonstrated
Keywords :
Monte Carlo methods; bioluminescence; biomedical MRI; biomedical measurement; biomedical optical imaging; image reconstruction; medical image processing; mesh generation; optical tomography; phantoms; Monte Carlo method; adaptive finite element analysis; adaptive finite element meshing; anatomical knowledge; bioluminescence sources; bioluminescence tomography; cellular activity; in vivo technique; micromagnetic resonance imaging; molecular activity; multiple constraints; multiscale method; multispectral measurements; optical knowledge; permissible source region refinement; reconstruction algorithms; reconstruction quality; small animal; virtual mouse phantom; whole-body level; Animals; Bioluminescence; Biomedical optical imaging; Finite element methods; Imaging phantoms; In vivo; Mice; Monte Carlo methods; Reconstruction algorithms; Tomography;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2007. ISBI 2007. 4th IEEE International Symposium on
Conference_Location :
Arlington, VA
Print_ISBN :
1-4244-0672-2
Electronic_ISBN :
1-4244-0672-2
DOI :
10.1109/ISBI.2007.356977
