Title :
The Inhibitory Effects of Chinese Herbal Effective Fractions on the Expression of EBV Early Antigen
Author :
Lv Xiuhua ; Liu Wei ; Hao Dongmei ; Liu Qiaoli ; Li Zelin ; Zeng Yi
Author_Institution :
Coll. of Life Sci. & Biotechnol., Beijing Univ. of Technol., Beijing, China
Abstract :
With the application of the immune enzyme assay, the inhibitory effects of Chinese herbal effective fractions on the expression of Epstein-Barr virus (EBV) early antigen in Raji cell have been investigated. The test result shows that astragalus polysaccharide (AP), ganoderma lucidum polysaccharide (GLP) and epimedium polysaccharide (EP) have inhibitory effects in certain range of dose. AP and GLP have significantly better inhibitory effects than EP. In addition, the inhibitory effects of these polysaccharides on EBV antigen expression have presented dose-effect relationships. In conclusion, this method can be used for finding new anti-EBV drugs in natural medicine. New anti-EBV drugs will inhibit EBV antigen expression and prevent cell carcinogenesis, so that they will be used for prevention and treatment of EBV associated disease. Furthermore the experiment reveals a new mechanism of herbal polysaccharides´ anti-viral and anti-tumor effects.
Keywords :
cancer; cellular biophysics; drugs; microorganisms; patient treatment; polymers; tumours; Chinese herbal effective fraction; EBV associated disease; EBV early antigen expression; Epstein-Barr virus; Raji cell; antiEBV drug; antitumor effect; astragalus polysaccharide; cell carcinogenesis; dose-effect relationship; epimedium polysaccharide inhibitory effect; ganoderma lucidum; herbal polysaccharide mechanism; Biochemistry; Biomembranes; Bovine; Chemicals; Diseases; Drugs; Filters; Immune system; Neoplasms; Testing;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5163628
