Multi-walled carbon nanotube coated microelectrode array for high-throughput, sensitive dopamine detection

Dopamine is a neurotransmitter that plays a key role in neural disorders. This paper reports on the design and fabrication of a microelectrode array (MEA) modified with multi-walled carbon nanotubes (MWCNTs) to detect dopamine with high sensitivity. The modification is based on covalent bonding of carboxylic groups in carbon nanotubes (CNTs) and amine groups in poly-l-lysin (PLL). The modified microelectrode array was characterized by Raman spectroscopy and electrochemical impedance spectroscopy (EIS). The CNT-coated MEA shows a sensitivity of 1186 nA/μM·mm²·(V/s)^0.5 in dopamine detection. This enhanced sensitivity suggests that CNT-coated MEA is a promising platform for in vitro high-throughput, high sensitivity neurotransmitter detection.