DocumentCode :
2532993
Title :
Mechanical vibrations reduce the Intervertebral Disc swelling and muscle atrophy from Bed Rest
Author :
Holguin, Nilsson ; Muir, Jesse ; Evans, Harlan J. ; Yi-Xian Qin ; Rubin, Clinton ; Wagshul, Mark ; Judex, Stefan
Author_Institution :
State Univ. of New York-Stony Brook, Stony Brook
fYear :
2007
fDate :
10-11 March 2007
Firstpage :
25
Lastpage :
26
Abstract :
Loss of functional weight bearing, such as experienced during space flight or bedrest, causes detrimental morphological volume changes to the intervertebral disc (IVD) beyond the normal diurnal cycle (10-13%), and muscle. Bed rest (BR) was used to test the hypothesis that, short-duration, low-magnitude, high-frequency mechanical vibrations will attenuate the IVD swelling and intrinsic back muscle atrophy induced by long-term bedrest. Control and experimental subjects underwent BR for up to 90d and were scanned by CT at Od and 90d, and by MRI at Od, 60d, 90d and 8d after completion of BR. In addition, experimental subjects received vibrations at 0.3g and 30Hz for lOmin/day. Muscle volume was measured by CT scans and IVD volume was measured by MRI scans. During BR, mechanical vibrations abated the IVD swelling at 60d by 150% and 90d by 65%. Eight days after bed rest, the control group showed a plasticity of 9%, while the experimental group showed no residual change (p>0.05). Mechanical vibrations reduced the intrinsic back muscle atrophy from long-term bed rest by 33% (p>0.05). These data demonstrate the rapid deterioration of the musculoskeletal system with BR but present vibrations as a promising non-pharmacologic countermeasure to disc degeneration and muscle atrophy.
Keywords :
aerospace biophysics; biomechanics; biomedical MRI; circadian rhythms; computerised tomography; muscle; neurophysiology; orthopaedics; vibrations; CT scan; IVD swelling; MRI scans; disc degeneration; diurnal cycle; functional weight bearing loss; intervertebral disc swelling; intrinsic back muscle atrophy; long-term bedrest; mechanical vibrations; morphological volume changes; musculoskeletal system deterioration; plasticity; space flight; time 0 day; time 60 d; time 8 d; time 90 d; Atrophy; Biomedical engineering; Biomedical measurements; Computed tomography; Frequency; Magnetic resonance imaging; Muscles; NASA; Vibration measurement; Volume measurement;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Bioengineering Conference, 2007. NEBC '07. IEEE 33rd Annual Northeast
Conference_Location :
Long Island, NY
Print_ISBN :
978-1-4244-1033-0
Electronic_ISBN :
978-1-4244-1033-0
Type :
conf
DOI :
10.1109/NEBC.2007.4413262
Filename :
4413262
Link To Document :
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