Title :
Cell apoptosis induced by atmospheric pressure plasma
Author :
Yong Yang ; Zilan Xiong ; Fei Zou ; XinPei Lu ; Xu Yan ; Shasha Zhao ; Guangxiao Yang ; Guangyuan He
Author_Institution :
Coll. of Electr. & Electron. Eng., Huazhong Univ. of Sci. & Technol., Wuhan, China
Abstract :
Reports show that atmospheric pressure cold plasma could induce cancer cell apoptosis in several minutes. However, up to now, only little has been known about the mechanism of plasma inducing cancer cell apoptosis. In this paper, an atmospheric pressure plasma plume is used to treat human hepatocellular carcinoma (HepG2) cell. Experimental results show that plasma can modulate the intracellular reactive oxygen species (ROS), and nitric oxide (NO) concentration. The relationship between the cell apoptosis and the concentrations of ROS, and NO is analysis. The results indicate that, firstly, the plasma generates NO, which increase the NO concentration of the cells outer environment. Secondly, the intracellular NO concentration is increased due to the NO diffusion from the medium. Thirdly, the intracellular ROS concentration is increased due to the increase of the intracellular NO concentration. Finally, the increase of the intracellular NO, and ROS concentrations result in the HepG2 cell apoptosis.
Keywords :
cancer; cellular biophysics; nitrogen compounds; patient treatment; plasma applications; plasma pressure; plasma temperature; HepG2 cell; NO; NO diffusion; atmospheric pressure cold plasma; atmospheric pressure plasma plume; cancer cell apoptosis; human hepatocellular carcinoma; intracellular reactive oxygen species; nitric oxide concentration; Cancer; Educational institutions; Helium; Humans; Plasmas;
Conference_Titel :
Plasma Science (ICOPS), 2012 Abstracts IEEE International Conference on
Conference_Location :
Edinburgh
Print_ISBN :
978-1-4577-2127-4
Electronic_ISBN :
0730-9244
DOI :
10.1109/PLASMA.2012.6383694