Breakthroughs in Photonics 2013: Quantitative Phase Imaging: Metrology Meets Biology

Author

Taewoo Kim ; Renjie Zhou ; Goddard, L.L. ; Popescu, Gabriel

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Illinois at Urbana-Champaign, Champaign, IL, USA

Volume

6

Issue

2

fYear

2014

fDate

Apr-14

Firstpage

1

Lastpage

9

Abstract

Quantitative phase imaging (QPI) is an emerging optical approach that measures the optical path length of a transparent specimen noninvasively. Therefore, it is suitable for studying unstained biological tissues and cells with high sensitivity and resolution. This capability of QPI has fueled itself to grow rapidly as an active field of study for the past two decades. With this trend, QPI has experienced some breakthroughs in methods and applications in the past year. We briefly review some of these breakthroughs in method, including QPI through silicon marker-free phase nanoscopy and white-light diffraction tomography. Furthermore, some of the applications, such as quantitative phase measurement of cell growth and real-time blood testing, are introduced to show the importance and applicability of the field.

Keywords

biological tissues; biomedical optical imaging; blood; cellular biophysics; light diffraction; optical tomography; phase measurement; transparency; QPI; biological tissues; cell growth; optical approach; optical path length; quantitative phase imaging; quantitative phase measurement; real-time blood testing; silicon marker-free phase nanoscopy; transparent specimen; white-light diffraction tomography; Biology; Deconvolution; Diffraction; Microscopy; Phase measurement; Three-dimensional displays; Optical imaging; interferometry; microscopy; phase measurement; tomography;

fLanguage

English

Journal_Title

Photonics Journal, IEEE

Publisher

ieee

ISSN

1943-0655

Type

jour

DOI

10.1109/JPHOT.2014.2309647

Filename

6762854