Title :
A Wireless Bio-MEMS Sensor for C-Reactive Protein Detection Based on Nanomechanics
Author :
Chen, C.-H. ; Hwang, R.-Z. ; Huang, L.-S. ; Lin, S. ; Chen, H.-C. ; Yang, Y.-C. ; Lin, Y.-T. ; Yu, S.-A. ; Wang, Y.-H. ; Chou, N.-K. ; Lu, S.S.
Author_Institution :
Nat. Taiwan Univ., Taipei
Abstract :
A quick (<30min.), label-free detection of disease-related C-reactive proteins (CRP) is achieved using a 200mum MEMS microcantilever housed in a 7times7mm2 reaction chamber. The deflection of the cantilever due to specific CRP/anti-CRP binding is detected using a position-sensitive photodiode and the converted bio-signal is transmitted by a wireless ASK transceiver IC fabricated in a 0.18mum CMOS process. CRP concentrations from 1mug/mL to 500mug/mL can be detected. A 0.2Hz 1V ac signal is applied to the bio-MEMS sensor to unbind CRP from the cantilever for reuse
Keywords :
biosensors; cantilevers; microsensors; photodiodes; proteins; 0.18 micron; 0.2 Hz; 1 V; 200 micron; C-reactive protein detection; CMOS process; CRP concentrations; MEMS microcantilever; MEMS sensor; biosensor; biosignal; label-free detection; nanomechanics; position-sensitive photodiode; reaction chamber; wireless ASK transceiver; wireless sensor; Amplitude shift keying; Biosensors; CMOS integrated circuits; CMOS process; Micromechanical devices; Photodiodes; Position sensitive particle detectors; Proteins; Transceivers; Wireless sensor networks;
Conference_Titel :
Solid-State Circuits Conference, 2006. ISSCC 2006. Digest of Technical Papers. IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
1-4244-0079-1
DOI :
10.1109/ISSCC.2006.1696292
