The effects of 50 Hz magnetic fields and/or phorbol ester TPA on proto-oncogene expression

Author

Wu, R.Y. ; Chiang, H. ; Fu, Y.D. ; Bao, J.L.

Author_Institution

Microwave Inst., Zhejiang Med. Univ., Hangzhou, China

Volume

6

fYear

1998

fDate

29 Oct-1 Nov 1998

Firstpage

3285

Abstract

This study is designed to validate key experiments on induction of c-myc and c-fos gene expression by MF and or/TPA under well controlled conditions. No significant effects of ELF MF alone on the gene expression was observed, but one interesting finding is that 0.4 and 0.8 mT 50 Hz magnetic field can strengthen c-fos expression in Daudi cells induced by TPA. It is the first time that the result directly prove that MF exposure can cooperate TPA induction in c-fos gene transcription

Keywords

biological effects of fields; biomagnetism; cellular effects of radiation; genetics; 0.4 mT; 0.8 mT; 50 Hz; Daudi cells; ELF fields; c-fos gene expression; c-myc gene expression; cancer link; cellular effects; gene transcription; magnetic fields effect; phorbol ester TPA effect; proto-oncogene expression; steady state transcript levels; Biomedical engineering; Coils; Electromagnetic fields; Gene expression; Geophysical measurement techniques; Ground penetrating radar; Humans; Laboratories; Magnetic field measurement; Magnetic shielding;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE

Conference_Location

Hong Kong

ISSN

1094-687X

Print_ISBN

0-7803-5164-9

Type

conf

DOI

10.1109/IEMBS.1998.746199

Filename

746199