Title :
Application of nanobiotechnology to construct a piezoelectric sensor matrix sensing the flexibility of immunoglobulin
Author :
Huang, G.S. ; Chen, Yu-Shiun ; Lin, Xin-Yau
Author_Institution :
Instititute of Nanotechnol., Nat. Chiao Tung Univ., Hsinchu
Abstract :
We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.
Keywords :
biosensors; coatings; gold; macromolecules; molecular biophysics; nanobiotechnology; nanoparticles; piezoelectric devices; SiO2-Au; antiserum; biological macromolecule; biosensor sensing; gold nanoparticles; immunoglobulin; nanobiotechnology; piezoelectric sensor matrix; quartz crystal microbalance; size 12 nm; size 3.5 nm; size 37 nm; size 5 nm; Biosensors; Chemistry; Economic indicators; Electrodes; Frequency; Gold; Immune system; Nanobiotechnology; Nanoparticles; Nanotechnology; Biosensor; Flexibility; Immunoglobulin; Matrix; Quartz Crystal Microbalance;
Conference_Titel :
Nanotechnology, 2007. IEEE-NANO 2007. 7th IEEE Conference on
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-0607-4
Electronic_ISBN :
978-1-4244-0608-1
DOI :
10.1109/NANO.2007.4601129
