Title :
Parallel adaptive finite element simulation for optical molecular imaging with simplified spherical harmonics approximation
Author :
Lu, Yujie ; Chatziioannou, Arion F.
Author_Institution :
Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 USA
Abstract :
Whole-body optical molecular imaging is rapidly developing for preclinical research. It is essential and necessary to develop novel simulation methods of light propagation for optical imaging, especially when a priori knowledge, large-volume domain and wide-range optical properties need to be considered in the reconstruction algorithm. In this paper, we develop a three dimensional parallel adaptive finite element method with simplified spherical harmonics (SPN) approximation to simulate photon propagation in large-volume heterogeneous tissues. Simulation speed is significantly improved by a posteriori parallel adaptive mesh refinement and dynamic mesh repartitioning. Compared with the diffusion equation, SPN method shows improved performance and the necessity of high-order approximation in heterogeneous domains. Optimal solver selection and time-costing analysis in real mouse geometry further improve the performance of the proposed algorithm.
Keywords :
Adaptive mesh refinement; Adaptive optics; Algorithm design and analysis; Equations; Finite element methods; Molecular imaging; Optical imaging; Optical propagation; Performance analysis; Reconstruction algorithms;
Conference_Titel :
Nuclear Science Symposium Conference Record, 2008. NSS '08. IEEE
Conference_Location :
Dresden, Germany
Print_ISBN :
978-1-4244-2714-7
Electronic_ISBN :
1095-7863
DOI :
10.1109/NSSMIC.2008.4774171