Title :
Bio-Inspired MEMS Devices for Electrical Cell Separation and Mechanical Cell Characterization
Author_Institution :
Korea Adv. Inst. of Sci. & Technol. (KAIST), Daejeon
Abstract :
We present a couple of bio-inspired microdevices for electrical cell separation and mechanical cell characterization, respectively. The electrical cell separator, inspired from ion-selective permeation mechanism in bio-membrane, performs size-dependent cell sorting functions using electrical pillar array. The mechanical cell characterization device, inspired from deformability-selective erythrocyte destruction mechanism in spleen, performs size-independent cell deformability monitoring functions using mechanical filter array. The structures and principles of the bio-inspired microdevices are presented and compared with those of the biological counter parts. The unique features and performance characteristics of the bio-inspired microdevices are analyzed and verified by experimental study. The cell separator illustrates an electrical method for size-dependent cell sorting insensitive to cell property, while the cell deformability sensor demonstrates a mechanical method for cell deformability monitoring insensitive to cell size. Additional advantages of the bio-inspired microdevices include simple structures and stable performance for applications to integrated biomedical systems.
Keywords :
bioMEMS; bioelectric phenomena; biomembrane transport; blood; permeability; bio-inspired MEMS devices; biomembrane; deformability-selective erythrocyte; electrical cell separation; electrical pillar array; integrated biomedical systems; ion-selective permeation; mechanical cell characterization; microdevices; size-dependent cell sorting; spleen; Biosensors; Counting circuits; Filters; Mechanical factors; Mechanical sensors; Microelectromechanical devices; Monitoring; Particle separators; Performance analysis; Sorting;
Conference_Titel :
Micro-NanoMechatronics and Human Science, 2007. MHS '07. International Symposium on
Conference_Location :
Nagoya
Print_ISBN :
978-1-4244-1858-9
Electronic_ISBN :
978-1-4244-1858-9
DOI :
10.1109/MHS.2007.4420909