Atmospheric pressure air plasma treatment of human blood plasma: a kinetic model of coagulation

Author

Fridman, G. ; Quann, K. ; Peddinghaus, M. ; Fridman, A. ; Balasubramanian, M. ; Gutsol, A. ; Brooks, A. ; Friedman, G.

Author_Institution

Drexel Plasma Inst., Drexel Univ., Philadelphia, PA

fYear

2006

fDate

4-8 June 2006

Firstpage

437

Lastpage

437

Abstract

Summary form only given. We observe that floating electrode dielectric barrier discharge (FE-DBD) electric plasma is able to significantly hasten human blood plasma clot formation and influence normal blood protein concentrations. Here, a better understanding of influence of FE-DBD is needed and we propose a first step in this direction - an explanation of influence of FE-DBD on ion concentrations in blood plasma. The presented model compares normal blood coagulation rate with blood undergoing e-plasma treatment by assuming linear relationship between ion concentrations in blood plasma and positive radical production by e-plasma at the surface of blood. Electric plasma is effective in increase of Ca²⁺ concentration through a redox mechanism: [Ca²⁺R^2-]+H_(H2O) ^-harrk_Ca|k_-Ca[H^-R^2-] _(H2O) ^-+Ca_(H2O) ^2-. This mechanism is provided by hydrogen ions generated in air plasma through a sequence of ion-molecular processes

Keywords

bioelectric phenomena; blood; coagulation; discharges (electric); molecular biophysics; plasma applications; plasma chemistry; plasma collision processes; proteins; reaction kinetics theory; atmospheric pressure air plasma treatment; blood protein concentrations; coagulation; electric plasma; floating electrode dielectric barrier discharge; human blood plasma clot formation; ion concentrations; ion-molecular processes; kinetic model; positive radical production; redox mechanism; Atmospheric modeling; Atmospheric-pressure plasmas; Blood; Coagulation; Dielectrics; Electrodes; Humans; Kinetic theory; Proteins; Water;

fLanguage

English

Publisher

ieee

Conference_Titel

Plasma Science, 2006. ICOPS 2006. IEEE Conference Record - Abstracts. The 33rd IEEE International Conference on

Conference_Location

Traverse City, MI

Print_ISBN

1-4244-0125-9

Type

conf

DOI

10.1109/PLASMA.2006.1707310

Filename

1707310