A coarse-grained cellular automaton model for hepatitis B viral infections

The basic model of hepatitis B virus (HBV) infection dynamics, are based on the assumption of well-mixed virus and cell populations. But spatial characteristics potentially play a nontrivial role in the development and outcome of a HBV infection, such as localized populations of dead cells might adversely affect the spread of infection. Here, we use a 2-D coarse-grained cellular automata model to study the evolution of HBV infection. We also consider the effects of the model´s parameters on the dynamics of the infection. The simulation results show that the model is powerful in simulating the process of HBV infection cell, and can be used to simulate the curative effects of different medication.